RU2380 CORM-3 Powder (CAS No.475473-26-8)

Catalog No.	RU2380
Purity	99.0 %
CAS Number	475473-26-8
Appearance	White powder
Molecular Formula	C5H4ClNO5Ru
Theoretical Metal Content	34.31 %

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RU2380 CORM-3 Powder (CAS No.475473-26-8)

Description

Specification

CORM-3 Powder Description

The enzymatic reaction of heme oxygenase inspired the development of synthetic CORMs. The first synthetic CORMs were typically metal carbonyl complexes. A representative CORM that has been extensively characterized both from a biochemical and pharmacological viewpoint is the ruthenium(II) complex Ru(glycinate)Cl(CO)3, commonly known as CORM-3.

CORM-3 Powder is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

CORM-3-powder

CORM-3 Powder Specifications

CAS Number	475473-26-8
Molecular Formula	C5H4ClNO5Ru
Molecular Weight	294.61
Synonyms	Carbon monoxide releasing molecule 3, Tricarbonylchloro(glycinato)ruthenium (II)
Appearance	White powder
Solubility	H2O: 20 mg/mL, clear

CORM-3 Powder Applications

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. CORM-3 Powder has also been used to study its protective function against H2O2-induced apoptosis using primary rabbit lens epithelial cells.