CORM-2 Powder Description
Carbon monoxide-releasing molecules (CORMs) are chemical compounds designed to release controlled amounts of carbon monoxide (CO). CORMs are being developed as potential therapeutic agents to locally deliver CO to cells and tissues, thus overcoming limitations of CO gas inhalation protocols.
CORM-2 Powder Specifications
CAS Number
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22594-69-0
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Molecular Formula
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[Ru(CO)3Cl2]2
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Molecular Weight
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512.02 g/mol
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Synonyms
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Tricarbonyldichlororuthenium(II) dimer; Carbon monoxide-releasing molecule
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Appearance
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White powder
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Density
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White to light yellow-green crystalline powder
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Solubility
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Soluble in DMSO
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CORM-2 Powder Applications
CORM-2 Powder can be used for pharmacological studies including:
- Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
- Investigations of P2X4 as a possible target
- Possible modification of thrombus growth or disintegration
- Enhances fibrinogen as a substrate for thrombin
- Regulation of ion transport by gasotransmitters
Besides, CORM-2 Powder can also be used as a CO donor for reactive oxygen species-mediated bacterial killing. Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.
CORM-2 Powder Safety Information
Symbol
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GHS07
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Signal Word
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Warning
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Hazard Statements
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H302 + H312 + H332-H315-H319-H335
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Precautionary Statements
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P261-P280-P305 + P351 + P338
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Personal Protective Equipment
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dust mask type N95 (US), Eyeshields, Gloves
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RIDADR
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NONH for all modes of transport
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WGK Germany
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3
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