Vitamin B1 Thiamine Hcl Introduction
Thiamine or thiamin or vitamin B1 named the “thio-vitamine” (“sulfur-containing vitamin”) is a water-soluble vitamin of the B complex. First named aneurin for the detrimental neurological effects if not present in the diet, it was eventually assigned the generic descriptor name vitamin B1. Its phosphate derivatives are involved in many cellular processes. The best-characterized form is thiamine pyrophosphate (TPP), a coenzyme in the catabolism of sugars and amino acids. Thiamine is used in the biosynthesis of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). In yeast, TPP is also required in the first step of alcoholic fermentation.
Vitamin B1 Thiamine Hcl Specification
ITEM |
STANDARD |
Appearance |
White or almost white, crystalline powder or colorless crystals |
Identification |
IR, Characteristic Reaction and Test of chlorides |
Assay |
98.5-101.0 |
pH |
2.7-3.3 |
Absorbance of solution |
=<0.025 |
Solubility |
Freely Soluble in Water, Soluble in Glycerol, Slightly Soluble in Alcohol |
Appearance of solution |
Clear and not more than Y7 |
Sulfates |
=<300PPM |
Limit of nitrate |
No brown ring is produced |
Heavy metals |
=<20 PPM |
Related substances |
Any impurity % =<0.4 |
Water |
=<5.0 |
Sulfated ash/Residue on ignition |
=<0.1 |
Chromatographic purity |
=<1.0 |
Vitamin B1 Thiamine Hcl Functions
Metabolic disorders. Taking thiamine by mouth helps correct metabolic disorders associated with genetic diseases, including Leigh’s disease, maple syrup urine disease, and others.
Thiamine deficiency. Taking thiamine by mouth helps prevent and treat thiamine deficiency.
Brain disorder due to thiamine deficiency (Wernicke-Korsakoff syndrome). Thiamine helps decrease the risk and symptoms of a specific brain disorder called Wernicke-Korsakoff syndrome (WKS). This brain disorder is related to low levels of thiamine (thiamine deficiency)
Athletic performance. Some research suggests that taking thiamine together with pantethine and pantothenic acid (vitamin B5) does not improve muscle strength or endurance in athletes.
Preventing cervical cancer. Some research suggests that increased intake of thiamine from dietary and supplement sources, along with other folic acids, riboflavin, and vitamin B12, might decrease the risk of precancerous spots on the cervix.
Cataracts. High thiamine intake as part of the diet is associated with a reduced risk of developing cataracts.
Kidney disease in people with diabetes. Early research shows that taking high-dose thiamine (100 mg three times daily) for 3 months decreases the amount of albumin in the urine in people with type 2 diabetes. Albumin in the urine is an indication of kidney damage.