Specifications of Swertiamarin
| Product Name |
Swertiamarin |
| CAS Registry Number |
17388-39-5 |
| Molecular Formula |
C16H22O10 |
| Molecular Weight |
374.3 g/mol |
| Purity |
10-95 % |
| Appearance |
Pale yellow powder |
| Package |
1kg-25kg |
| Shelf life |
2 years |
| Functions |
anti-hyperglycemic, anti-hyperlipidemic, anti-diabetic activity, enhances β cell regeneration |
Description of Swertiamarin
Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties. Swertiamarin (50 μg/ml) inhibits nitric oxide (NO) production in IL-1β-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaws.
Swertiamarin (25 μg/ml) inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells. It decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced nonalcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg per day. Swertiamarin (50 mg/kg per day) also decreases fasting blood glucose and serum cholesterol levels in a rat model of diabetes induced by streptozotocin.
Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic, and hypolipidemic activities.
Applications of Swertiamarin
- Laboratory research
- Raw materials for hair regeneration products
Laboratory Research:
- Therapeutic Potential: Researchers are actively investigating swertiamarin's therapeutic potential, examining its impact on various biological processes. Studies focus on its anti-inflammatory, antioxidant, and anti-cancer properties, providing valuable insights into its potential health benefits.
- Versatility: Swertiamarin's versatility as a natural compound makes it an essential component in laboratory experiments, contributing to the exploration of its diverse pharmacological effects across multiple scientific disciplines.
Raw Materials for Hair Regeneration Products:
- Natural Hair Care: Swertiamarin plays a pivotal role in the cosmetic and pharmaceutical industries as a raw material for hair regeneration products. Its inclusion aligns with the growing trend of using natural and botanical ingredients in hair care formulations.
- Promoting Hair Growth: As a key ingredient, swertiamarin contributes to innovative solutions aimed at addressing hair loss concerns and promoting overall scalp health. Its presence underscores its potential to stimulate hair growth and enhance the efficacy of products designed for hair regeneration.
Reference:
- Vaijanathappa, J., and Badami, S. Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. Planta Med. 75(1), 12-17 (2009).
- Saravanan, S., Islam, V.I., Thirugnanasambantham, K., et al. Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes. Inflamm. Res. 63(6), 451-462 (2014).
- Sonawane, R.D., Vishwakarma, S.L., Lakshmi, S., et al. Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol. Cell Biochem. 340(1-2), 1-6 (2010).
- Patel, T.P., Rawal, K., Soni, S., et al. Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. Biomed. Pharmacother. 83, 785-791 (2016).
- Yang, Y., Li, J., Wei, C., et al. Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. Phytomedicine 59, 152782 (2019).
